Full directory listing B.A. Chemistry, DePauw University, 1966
Ph.D. Organic and Physical Chemistry, University of Illinois, Urbana, 1970
Post-doctoral, University of California, Los Angeles, Physical Chemistry, 1970-1972
Research
The overall goal of our research is to develop the field of Solid State Chemistry of Drugs so that all of the principles and factors governing solid state chemistry are understood. This knowledge will then be used to predict and analyze all behaviors of solids observed during the drug development process. Thus, the solid state chemistry of drugs is being studied to improve knowledge of the factors which affect this chemistry and to develop new methods of studying these reactions. At present, our group is focusing on solid state oxidation reaction of drugs, including the oxidations of peptides and amino acids which contain solvent of crystallization. We are also investigating solid state desolvation reactions, solid state decarboxylation reactions, solid-solid reactions, and solid state rearrangements. These studies are important in that they will lead to better understanding of the mechanism of drug degradation and eventually to new approaches to stabilizing drugs. Recently we have begun a major new study of the effect of moisture on the mobility of pharmaceutical solids using solid state NMR spectroscopy. In particular, we are correlating the structure of solids with their solid state NMR spectra. In addition, we are focusing on determining the relationship between thermal motion as measured by solid state NMR spectroscopy and X-ray crystallography, and solid state reactivity. This research has implications for the analysis of drugs, the stability of drugs, the control of drug production, and the development of methods of crystallization. By carrying out research on the solid state chemistry of drugs it is hoped that new approaches and ideas for drug analysis including solid state NMR spectroscopy will be developed. In addition, this research is aimed at providing new insight into drug stability and at developing methods for predicting drug stability. Furthermore, approaches to the production via crystallization of the desired drug form are an important component of these studies.
G.A. Stephenson, T.J. Wozniak, J.G. Stowell, and S.R. Byrn, "Nizatidine, N-[2-[[[2[(dimethylamino)methyl]-4-thiazoyl]methyl]thio]ethyl]-N�-methyl-2-nitro-1,1- ethenediamine." J. Mol. Struct., 380, 93-100 (1996).
G.A. Stephenson, R.R. Pfeiffer, S.R. Byrn, "Solid-state investigation of the tautomerism of acetohexamide." Int. J. Pharm., 146(1), 93-99 (1997).
C. Kim, W.C. MacKellar, N. Cho, S.R. Byrn, D.J. Morre, "Impermeant antitumor sulfonylurea conjugates that inhibit plasma membrane NADH oxidase and growth of HeLa cells in culture. Identification of binding proteins from sera of cancer patients." Biochim. Biophys. Acta, 1324(2), 171-181 (1997).
E.Y. Shalaev, S.R. Byrn, G. Zografi, "Single-phase and heterophase solid-state chemical kinetics of thermally induced methyl transfer in tetraglycine methyl ester." Int. J. Chem. Kinet., 29(5), 339-348 (1997)
K-S. Huang, D. Britton, M.C. Etter, S.R. Byrn, "A novel class of phenol-pyridine co-crystals for second harmonic generation." J. Mater. Chem., 7(5), 713-720 (1997).
G.P. Stahly, A.T. McKenzie, M.C. Andres, C.A. Russell, S.R. Byrn, P. Johnson, "Determination of the Optical Purity of Ibuprofen Using X-ray Powder Diffraction." J. Pharm. Sci., 86(8), 970-971 (1997)
E.Y. Shalaev, M. Shalaeva, S.R. Byrn, G. Zografi, "Effects of processing on the solid-state methyl transfer of tetraglycine methyl ester." Int. J. Pharm., 152(1), 75-88 (1997.)
Curriculum Vitae
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This record was last updated on Jan 2, 2008 at 10:09 AM
